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What is Syphilis?

Syphilis is a sexually transmitted infection that is treatable with medication. Without treatment syphilis can cause serious health problem, possibly leading to permanent damage to the eyes, ears, brain, or heart.

Syphilis During Pregnancy

Congenital syphilis (CS) occurs when a mother with syphilis passes the infection on to her baby during pregnancy. Syphilis testing and treatment as early as possible in the pregnancy can help prevent a baby from major CS complications.

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Syphilis Toolkit for Healthcare Providers

Health care providers can play a critically important role in helping to reduce syphilis in suburban Cook County by taking the following actions: Report, Test & Diagnose, Stage & Treat, and Prevent.

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What is
Syphilis?

Bicillin L-A® Shortage

The only medication available to treat pregnant people with syphilis and babies with congenital syphilis is in short supply. Healthcare providers are encouraged to prioritize Bicillin L-A® for these populations. Pfizer anticipates this shortage until early- to mid-2024. The Food and Drug Administration is now allowing the temporary importation of Extencilline (benzathine benzylpenicillin) which is an equivalent injectable medication until supplies of Bicillin are replenished. It is only available by prescription in the United States.

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Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. Syphilis is most infectious during the early, primary, and secondary stages. Primary and secondary syphilis infections will cause sores (chancres), and then rashes, among other symptoms. Sores and rashes are not always apparent or may be internal and hard to find.
 
Syphilis is spread when one comes in close, direct contact with sores or rashes during vaginal, anal, or oral sex.  Syphilis infections may also spread from a pregnant person with an untreated infection to their baby in utero. When a baby gets syphilis from their parent it is called congenital syphilis. Learn more about congenital syphilis here.

Syphilis in suburban Cook County

The number of primary and secondary syphilis (PSS) cases in suburban Cook County nearly tripled from 2014 (n=69) to 2021 (n=206) in 2021, but were stable from 2022 (n=159) to 2023 (n=157). The number of PSS cases in 2023 were the lowest reported since 2015 (n=146).
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View our 2023 Sexually Transmitted Infections Surveillance Report here, and previous reports here.

Who is Most At Risk For Syphilis

%

40%

40% of syphilis cases are ages 20-29 years old

%

25%

25% of primary and secondary syphilis cases are ages 20-24 years old

%

90%

90% of primary and secondary syphilis cases in suburban Cook County are male

%

57%

57% are non-Hispanic Black

%

22%

22% are non-Hispanic White

%

16%

16% are Hispanic/Latino

What sexually active people can do to prevent syphilis

To reduce the number of syphilis cases, we all need to work together: Health departments, health care providers, and everyone who is sexually active.

Get Tested

Anyone at increased risk should be tested for syphilis. This includes individuals who are pregnant, men who have sex with men (MSM), people living with HIV, and anyone whose partner has been recently diagnosed with syphilis. Testing is also recommended for those who have new or multiple sexual partners, have a partner with unknown STI or HIV status, or use hookup apps or online platforms to meet sexual partners. Regular testing is essential to ensure early detection and treatment.

Use Condoms

If you need condoms, let us know. We will mail them to you. Use condoms the right way every time you have oral, anal or vaginal sex including hookups arranged through an app.

Talk with us

We’re here to help, not make judgments. We can also help you notify your partners or notify them if you aren’t able to. If someone from the health department is trying to contact you, chances are it’s important. Find out what they have to say. We want everyone who is sexually active to be as healthy as possible and to be infection-free – and stay that way. You can email us at [email protected]

Get Treated 

Syphilis can be treated with antibiotics from your provider, and the earlier it’s diagnosed, the better. Untreated, syphilis can

  • spread to others;
  • make it more likely for you to get or spread HIV
  • spread from a mother to her unborn baby and cause a miscarriage, stillbirth (a baby born dead), deformed bones, or other severe health problems
  • cause other major health problems, even 30 years after the initial symptoms go away

Updated October 30, 2025, 9:48 AM